Erasure of Tet-Oxidized 5-Methylcytosine by a SRAP Nuclease
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چکیده
منابع مشابه
Mechanisms and functions of Tet protein-mediated 5-methylcytosine oxidation.
Ten-eleven translocation 1-3 (Tet1-3) proteins have recently been discovered in mammalian cells to be members of a family of DNA hydroxylases that possess enzymatic activity toward the methyl mark on the 5-position of cytosine (5-methylcytosine [5mC]), a well-characterized epigenetic modification that has essential roles in regulating gene expression and maintaining cellular identity. Tet prote...
متن کاملMamta Tahiliani , MLL Partner TET 1 5 - Hydroxymethylcytosine in Mammalian DNA by Conversion of 5 - Methylcytosine
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متن کاملTET proteins and 5-methylcytosine oxidation in the immune system.
DNA methylation in the form of 5-methylcytosine (5mC) is essential for normal development in mammals and influences a variety of biological processes, including transcriptional regulation, imprinting, and the maintenance of genomic stability. The recent discovery of TET proteins, which oxidize 5mC to 5-hydroxymethylcytosine, 5-formylcytosine, and 5-carboxylcytosine, has changed our understandin...
متن کاملTet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.
5-methylcytosine (5mC) in DNA plays an important role in gene expression, genomic imprinting, and suppression of transposable elements. 5mC can be converted to 5-hydroxymethylcytosine (5hmC) by the Tet (ten eleven translocation) proteins. Here, we show that, in addition to 5hmC, the Tet proteins can generate 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) from 5mC in an enzymatic activity-...
متن کاملDynamic Readers for 5-(Hydroxy)Methylcytosine and Its Oxidized Derivatives
Tet proteins oxidize 5-methylcytosine (mC) to generate 5-hydroxymethyl (hmC), 5-formyl (fC), and 5-carboxylcytosine (caC). The exact function of these oxidative cytosine bases remains elusive. We applied quantitative mass-spectrometry-based proteomics to identify readers for mC and hmC in mouse embryonic stem cells (mESC), neuronal progenitor cells (NPC), and adult mouse brain tissue. Readers f...
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ژورنال
عنوان ژورنال: Cell Reports
سال: 2017
ISSN: 2211-1247
DOI: 10.1016/j.celrep.2017.09.055